Endocrine Abstracts

After they are released from the testis, spermatozoa pass into the epididymis where they mature. The epididymis is a single, highly coiled duct that develops from a portion of the embryonic Wolffian duct (WD) under the control of testosterone. We have used a model system in which the androgen receptor (AR) antagonist flutamide is administered to pregnant rats to investigate the cellular mechanisms responsible for androgen-dependent WD differentiation.Tim...